Fever as a Sign of Quinidine Toxicity

TOXIC reactions to quinidine are often dermal or gastrointestinal except when large doses cause myocardial disturbances, such as intraventricular block, ventricular tachycardia and ventricular fibrillation.In 1952 Berley and Saland1 called attention to the relatively uncommon occurrence of drug fever from quinidine, and stated that 5 cases had been reported. In 3 of these there were also skin reactions. The authors presented 2 more cases in which fever was the only evidence of toxicity.Rose, Vogl and Turtz,2 in 1953, reviewed the literature and added 3 cases of their own. These, the 2 described by Levy3 and the 2 cases . . .