Why the study?
Does plasma quinidine concentration correlate with symptoms of quinidine toxicity?
Does plasma quinidine concentration correlate with symptoms of quinidine toxicity?
Gastrointestinal symptoms of quinidine toxicity do not correlate with plasma concentration, whereas neurological and hypotensive symptoms occur at higher concentrations.
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GI symptoms warrant vigilance at any quinidine level; leaves open concentration-guided monitoring for neurological or hypotensive toxicity.
The gastrointestinal symptoms of quinidine toxicity occurred without relation to plasma concentration, suggesting that most examples are due to individual local gastrointestinal sensitivity and some, associated with giddiness, occur only at higher levels and may be due to nervous system effects. Tinnitus, visual disturbances and marked hypotension generally occurred at relatively high plasma quinidine concentrations. It is suggested that hypotension is due to a nervous system effect rather than to myocardial incompetence, but nonetheless warrants cessation of administration.
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Kalmansohn et al. (1950) studied this question.
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