Key result
Coated quinidine sulfate tablets produced delayed but similar maximum serum concentrations compared to uncoated tablets, with higher levels persisting for 12 hours.
Why the study?
Does delayed-absorption coated quinidine sulfate alter blood serum concentration curves compared to uncoated tablets?
Does delayed-absorption coated quinidine sulfate alter blood serum concentration curves compared to uncoated tablets?
Coated quinidine sulfate tablets delay absorption, providing sustained overnight drug levels that may help prevent nocturnal arrhythmias and reduce nausea.
May support coated quinidine for sustained overnight levels; leaves open effects on arrhythmia prevention or tolerability.
Quinidine sulfate, orally administered in tablets coated with a material delaying their absorption, produces concentration curves in the blood serum similar to those of uncoated tablets. However, there is a delay in the appearance and the attaining of maximum concentrations with the coated tablets, although higher levels may persist for 12 hours. Defects in coating may cause faulty failure of absorption. The advantages of using such a preparation of quinidine are: (1) avoidance of nausea in susceptible persons, (2) providing effective concentrations of the drug during the night and thereby preventing nocturnal attacks of arrhythmias, and (3) providing greater concentrations of the drug in the morning, when attempts at conversions of arrhythmias may require therapy over several days or more.
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Sampson et al. (1952) studied this question. Coated quinidine sulfate tablets vs. Uncoated quinidine sulfate tablets was evaluated on Blood serum concentration curves. Coated quinidine sulfate tablets produced delayed but similar maximum serum concentrations compared to uncoated tablets, with higher levels persisting for 12 hours.
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