Why the study?
Do different quinidine formulations produce different pharmacokinetic profiles during chronic administration?
Population
Subjects receiving chronic administration of quinidine (specific details not provided in abstract)
Comparison
Four different quinidine formulations vs Compared against each other
Design
Other
Authors
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May support twice-daily sustained-release quinidine dosing; leaves open need for outcome trials before practice change.
Do different quinidine formulations produce different pharmacokinetic profiles during chronic administration?
Sustained-release quinidine bisulphate formulations allow for safe and effective twice-daily dosing by maintaining stable serum levels.
Soeterboek et al. (1976) studied this question.
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