Key result
Quinidine polygalacturonate and bisulphate showed similar absorption extent to quinidine sulphate, whereas quinidine arabogalactansulphate exhibited lower bioavailability.
Why the study?
How do the pharmacokinetics of different short- and long-acting quinidine formulations compare to rapidly dissolving quinidine sulphate in healthy male volunteers?
How do the pharmacokinetics of different short- and long-acting quinidine formulations compare to rapidly dissolving quinidine sulphate in healthy male volunteers?
Quinidine bisulphate provides delayed peak levels with equivalent bioavailability to quinidine sulphate, whereas quinidine arabogalactansulphate has lower bioavailability.
May inform quinidine formulation selection by bioavailability; leaves open effects on efficacy or safety in patients.
1 The time-course of quinidine plasma concentrations and selected kinetic parameters were studied in healthy male volunteers given single oral doses of four different quinidine formulations. Comparison was made with quinidine sulphate in a rapidly dissolving form. 2 Plasma half-lives did not significantly differ among treatments. 3 Quinidine polygalacturonate appears to be equivalent to quinidine sulphate in respect to both the absorption and elimination kinetics. When both quinidine bisulphate (Kinidin Durules) and quinidine arabogalactansulphate (Longacor) were administered plasma levels peaked significantly later than after quinidine sulphate. However, while the former seems to be absorbed to the same extent as quinidine sulphate, the latter exhibits lower bioavailability in respect to all other preparations.
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Frigo et al. (1977) studied Healthy. Quinidine polygalacturonate, quinidine bisulphate, and quinidine arabogalactansulphate vs. Quinidine sulphate was evaluated on Time-course of quinidine plasma concentrations and selected kinetic parameters. Quinidine polygalacturonate and bisulphate showed similar absorption extent to quinidine sulphate, whereas quinidine arabogalactansulphate exhibited lower bioavailability.
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