Why the study?
Does quinidine at steady state compared to a single dose alter its pharmacokinetics and pharmacodynamics?
Comparison
Quinidine at steady state (200 mg every 6 h) vs Quinidine single dose (400 mg)
Design
Other
Authors
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May warrant closer QTc monitoring at quinidine steady state; leaves open validation in larger cohorts.
Does quinidine at steady state compared to a single dose alter its pharmacokinetics and pharmacodynamics?
Quinidine exhibits time-dependent pharmacokinetics and pharmacodynamics, with lower clearance and a steeper concentration-QTc relationship at steady state compared to a single dose.
Wooding‐Scott et al. (1988) studied this question.
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