Key result
An oral loading dose of 600-800 mg of quinidine sulphate achieved therapeutic plasma concentrations (2-4 microgram/ml) within 3 hours in the majority of cardiac patients.
Why the study?
Does an oral loading dose and 12-hour maintenance interval of quinidine achieve therapeutic plasma concentrations in cardiac patients?
Population
52 cardiac patients
Comparison
Oral loading dose of 600-800 mg rapidly absorbed… vs Maintenance therapy with sustained release…
Design
Cohort
Authors
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May support oral quinidine loading for rapid therapeutic levels in cardiac patients; leaves open need for monitoring and prospective validation.
Does an oral loading dose and 12-hour maintenance interval of quinidine achieve therapeutic plasma concentrations in cardiac patients?
An oral loading dose of 600-800 mg of quinidine followed by 12-hourly sustained-release maintenance therapy achieves therapeutic plasma concentrations, though individual variation necessitates monitoring.
Collste et al. (1979) studied Cardiac patients requiring quinidine therapy (n=52). Quinidine was evaluated on Plasma concentrations of quinidine. An oral loading dose of 600-800 mg of quinidine sulphate achieved therapeutic plasma concentrations (2-4 microgram/ml) within 3 hours in the majority of cardiac patients.
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