September 18, 2003Fundamental and Clinical Pharmacology

The preventive effect of captopril or enalapril on reperfusion injury of the kidney of rats is independent of angiotensin II AT1 receptors

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Why the study?

Do ACE inhibitors or AT1 receptor blockers prevent renal reperfusion injury in a rat model?

Population

Female rats weighing 200-250 g subjected to renal reperfusion injury

Comparison

Captopril, enalapril, or losartan administered… vs Appropriate controls (untreated/vehicle)

Design

Preclinical

Authors

HPHamidreza Pazoki–ToroudiIran University of Medical Sciences AHAli HesamiIran University of Medical Sciences SVSimin VahidiChildren's Medical Center

Discussion

Member takes

Implication

Should not change clinical practice; hypothesis-generating for non-AT1 mechanisms of ACE inhibitors in rat reperfusion injury.

Structured PICO

Do ACE inhibitors or AT1 receptor blockers prevent renal reperfusion injury in a rat model?

Population

Female rats weighing 200-250 g subjected to renal reperfusion injury

Intervention

Captopril (5, 20, 80 mg/kg), enalapril (1, 4, 16 mg/kg), or losartan (5, 10, 20 mg/kg) administered subcutaneously 120 min prior to the initiation of reperfusion injury

Comparator

Appropriate controls (untreated/vehicle)

Outcome

Histological presence and grading of ischaemic injury in the kidneysurrogate

ACE inhibitors prevent renal reperfusion injury in rats through mechanisms independent of the AT1 receptor.

Cite This Study

Pazoki–Toroudi et al. (2003) studied this question.

synapsesocial.com/papers/6a8bd92052e1a91077e97fbc https://doi.org/10.1046/j.1472-8206.2003.00188.x

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