CXC Chemokine Ligand 16 Promotes the Proliferation and Migration of Hodgkin and Reed-Sternberg Cells Via the PI3K/Akt/NF-κB Signaling Pathway

This is the authors' abstract. We don't add key points for this paper.

Hodgkin's Lymphoma (HL) is one of the most common malignant neoplasms affecting hematological and lymphoid systems. The leading causes of poor prognosis in HL correlate with tumor invasion and metastasis. Hodgkin and Reed-Sternberg (H/RS) cells, although only accounting for less than 1% of total HL tumor cells, contribute considerably to tumor progression The mechanism may involve immune escaping which was conducted by interaction of various cytokines and chemokines between tumor cells and inflammatory cells in the tumor microenvironment