Background: The use of lopinavir/ritonavir (LPV/r) may cause gonadal hormone dysfunction as an adverse consequence. Melatonin (MT) and alpha lipoic acid (ALA) have been associated with the regulations of gonadal functions. Objectives: The current study investigated the protective effects of MT and ALA against LPV/r-induced alterations in gonadal hormones of male albino rats. Methods: Rats were randomized into groups and were orally supplemented with MT (10mg/kg), ALA (10mg/kg) and MT + ALA prior to treatment with LPV/r (22.9/5.71-91.4/22.9 mg/kg) daily for 90 days, respectively. Rats were sacrificed, blood samples were collected, and sera were extracted and evaluated for luteinizing hormone (LH), folliclestimulating hormone (FSH), testosterone (T), prolactin (PRL) and estradiol (ED). Results: Significant (p<0.001) decreases in serum LH, FSH, and T levels with significant (p<0.001) increases in PRL and ED levels in a dose-related fashion occurred in LPV/r-treated rats when compared to control. However, serum LH, FSH, T, PRL and ED levels were significantly restored in rats supplemented with MT (p<0.01), ALA (p<0.01) and MT+ALA (p<0.001) when compared to LPV/r-treated rats. Conclusion: This study showed that MT and ALA restored serum gonadal hormones of LPV/r-treated rats.
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Adikwu et al. (2022) studied this question.
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