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Demonstrates breed-dependent arterial lesion severity under cholesterol-fat diets despite equivalent serum cholesterol in pigeons, suggesting genetic determinants in lesion complexity.
Cholesterol-fat diets are markedly more atherogenic when fed to a strain of pigeons susceptible to spontaneous atherosclerosis, as compared to a strain resistant to the disease. A breed of pigeons intermediate in susceptibility was found to be intermediate in their response to a high cholesterol-high fat diet. Serum cholesterol levels were similar among the three breeds. The White Carneau pigeons developed lesions complicated by connective tissue proliferation while the Autosexing Kings and Racing Homers developed merely "pure atheroma" or "fatty streaks."
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Clarkson et al. (1961) studied this question.
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