Key result
Isotopic cholesterol influx and efflux rates were progressively higher in fatty streaks and atheromatous plaques compared to normal aorta, with plaques appearing to be in positive cholesterol balance.
Population
Cholesterol-fed White Carneau pigeons
Comparison
Isotopic cholesterol administered per os for 30… vs Comparison between normal aortic tissue, fatty…
Design
Preclinical
Follow-up
Up to 100 days after cessation of 30-day isotope…
Authors
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Supports net cholesterol retention in atheroma; hypothesis-generating for human plaque dynamics and requires clinical validation.
This preclinical study demonstrates that atherosclerotic plaques and fatty streaks have a positive cholesterol balance driven by increased influx of both free and esterified cholesterol compared to normal aortic tissue.
Lofland et al. (1970) studied Atherosclerosis. Isotopic cholesterol was evaluated on Rates of influx and efflux of plasma cholesterol in different aortic tissues. Isotopic cholesterol influx and efflux rates were progressively higher in fatty streaks and atheromatous plaques compared to normal aorta, with plaques appearing to be in positive cholesterol balance.
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