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October 23, 2024Diseases of the Colon & RectumOpen Access

Impact of Anastomotic Leakage After Colorectal Cancer Surgery on Quality of Life: A Systematic Review

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Why the study?

Limited research has examined the impact of colorectal anastomotic leakage, a frequent and dreaded complication, on quality of life after colorectal cancer surgery.

Does anastomotic leakage after oncological colorectal resection impair quality of life?

Comparison

Patients with anastomotic leakage vs without anastomotic leakage

Design

Systematic review

Follow-up

1 month to 14 years

Authors

AGAnke H. C. GielenDHDanique J. I. HeuvelingsPSPatricia Sylla

Discussion

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Overview

Anastomotic leakage impairs postoperative quality of life after colorectal cancer resection, especially in the first year; extends observational evidence and supports targeted prevention trials.

Structured PICO

Does anastomotic leakage after oncological colorectal resection impair quality of life?

P
Population
4,618 patients who underwent oncological colorectal resections across 13 studies
I
Intervention
Anastomotic leakage (n=527)
C
Comparator
No anastomotic leakage
O
Outcome
Quality of life measured using validated questionnairespatient reported

Anastomotic leakage after colorectal cancer surgery significantly impairs patient quality of life, particularly within the first postoperative year.

Limitations

  • High heterogeneity between the included studies based on the questionnaires used and the time of assessment

Cite This Study

Gielen et al. (2024) studied this question.

synapsesocial.com/papers/6a8bdfbfc12eaf65c8b22146https://doi.org/10.1097/dcr.0000000000003478
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Rayyan—a web and mobile app for systematic reviews2016 · 26,566 citations
  2. 2Diagnosis, treatment, and consequences of anastomotic leakage in colorectal surgery2017 · 269 citations
  3. 3Comorbidities are associated with poorer quality of life and functioning and worse symptoms in the 5 years following colorectal cancer surgery: Results from the ColoREctal Well‐being (CREW) cohort study2018 · 64 citations
  4. 4An International Collaborative Standardizing a Comprehensive Patient-Centered Outcomes Measurement Set for Colorectal Cancer2017 · 138 citations
  5. 5The effect of anastomotic leak on postoperative pelvic function and quality of life in rectal cancer patients2022 · 14 citations