Why the study?
Anastomotic leakage is a life-threatening complication after colorectal surgery, but its impact on long-term survival and local recurrence remains discussed in the literature.
Does anastomotic leakage after elective colorectal cancer resection reduce overall survival, disease-free survival, and local recurrence rate in patients with colorectal cancer?
Population
94 patients with anastomotic leakage and 94 matched controls from 1122 colorectal cancer resection patients
Comparison
Anastomotic leakage vs no anastomotic leakage
Design
Retrospective monocentric 1:1 propensity score-matched pairs analysis
Authors
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Anastomotic leak may worsen long-term survival and raise local recurrence risk after colorectal cancer resection; leaves open whether targeted prevention alters oncologic outcomes.
Does anastomotic leakage after elective colorectal cancer resection reduce overall survival, disease-free survival, and local recurrence rate in patients with colorectal cancer?
Anastomotic leakage after elective colorectal cancer resection does not significantly impact long-term overall survival, disease-free survival, or local recurrence rate when adjusting for confounders via propensity score matching.
Zimmermann et al. (2018) studied this question.
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