Enantioselective Synthesis of Axially Chiral 1‐Arylisoquinolines by Rhodium‐Catalyzed [2+2+2] Cycloaddition

It's all in the application! An enantioselective synthesis of axially chiral 1-arylisoquinolines has been achieved, which involves a rhodium-catalyzed [2+2+2] cycloaddition of diphenylphosphinoyl-substituted 1-arylisoquinolines (see scheme). The new diphenylphosphinoyl-substituted axially chiral 1-arylisoquinolines were successfully derivatized to the corresponding axially chiral P,N ligand and Lewis base catalyst.