May 15, 2013Gut and LiverOpen Access

Use of Antithrombin and Thrombomodulin in the Management of Disseminated Intravascular Coagulation in Patients with Acute Cholangitis

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Why the study?

Does a treatment algorithm using antithrombin and thrombomodulin improve DIC reversal rates in patients with acute cholangitis complicated by DIC?

Structured PICO

Does a treatment algorithm using antithrombin and thrombomodulin improve DIC reversal rates in patients with acute cholangitis complicated by DIC?

Population

Patients with disseminated intravascular coagulation (DIC) complicating acute cholangitis

Intervention

Treatment algorithm using antithrombin (AT) and thrombomodulin (rTM) based on plasma AT III levels at the time of DIC diagnosis and DIC score changes on treatment day 3

Outcome

DIC reversal rates on day 7 and DIC score changessurrogate

A treatment algorithm utilizing antithrombin and thrombomodulin achieved >75% DIC reversal rates by day 7 in patients with acute cholangitis.

Discussion

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Implication

May support algorithm in cholangitis-DIC; hypothesis-generating pending randomized confirmation.

Cite This Study

Nakahara et al. (2013) studied this question.

synapsesocial.com/papers/6a8be30160c8c47a9ee3f0c5 https://doi.org/10.5009/gnl.2013.7.3.363

View Full Paper

Ask AI

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Use of Antithrombin and Thrombomodulin in the Management of Disseminated Intravascular Coagulation in Patients with Acute Cholangitis

Structured PICO

Discussion

Implication

Cite This Study

Use of Antithrombin and Thrombomodulin in the Management of Disseminated Intravascular Coagulation in Patients with Acute Cholangitis

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider