Key result
Anticoagulants may improve survival and DIC scores post-gastrointestinal surgery without increasing bleeding.
Why the study?
Many studies about anticoagulant therapy for DIC have confused gastrointestinal surgery-related DIC with DIC unrelated to prior operations, complicating assessment of efficacy and safety.
Does anticoagulant therapy improve outcomes and survival without increasing bleeding in patients with DIC after gastrointestinal surgery?
Systematic Review
Does anticoagulant therapy improve outcomes and survival without increasing bleeding in patients with DIC after gastrointestinal surgery?
Anticoagulant therapy, particularly recombinant thrombomodulin, appears effective and safe for managing DIC following gastrointestinal surgery without increasing bleeding risks.
May support anticoagulant use in post-GI surgery DIC; extends evidence to this surgical subgroup.
Many studies about anticoagulant therapy for disseminated intravascular coagulation (DIC) confused gastrointestinal surgery-related DIC with DIC unrelated to a prior operation. Furthermore, the potentially increased risk of bleeding by anticoagulants complicates their use. We carried out a systematic review to describe the efficacy and safety of anticoagulant agents for DIC after gastrointestinal surgery. Several studies have indicated that gabexate mesylate improves DIC score without increasing bleeding events, and that antithrombin is associated with lower mortality of DIC after gastrointestinal surgery. Recombinant thrombomodulin has been the most frequently analyzed anticoagulant agent in this field. DIC score and survival rate were better in patients treated with recombinant thrombomodulin, without increasing bleeding events. In conclusion, anticoagulant therapy may be effective and safe in DIC after gastrointestinal surgery.
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Hashimoto et al. (2018) conducted a systematic review in Disseminated intravascular coagulation (DIC) after gastrointestinal surgery. Anticoagulant therapy was evaluated on Efficacy (DIC score, survival rate) and safety (bleeding events). Anticoagulant therapy may improve DIC scores and survival without increasing bleeding events in patients with disseminated intravascular coagulation after gastrointestinal surgery.
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