Why the study?
Neurologic manifestations are known to occur rarely during adenovirus infection, prompting analysis of clinical, laboratory, and outcome features alongside cerebrospinal fluid viral detection.
Comparison
Positive vs negative cerebrospinal fluid adenovirus polymerase chain reaction
Design
Retrospective study
Authors
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Positive CSF Adv PCR links to younger onset without differing features; leaves open whether PCR status indicates CNS involvement or severity in children.
Adenovirus is a rare cause of CNS disease in children, and the absence of the virus in the CSF does not exclude CNS involvement nor indicate disease severity.
Zhang et al. (2020) studied this question.
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