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April 20, 2012Journal of Clinical MicrobiologyOpen Access

Comparison of the Luminex xTAG RVP Fast Assay and the Idaho Technology FilmArray RP Assay for Detection of Respiratory Viruses in Pediatric Patients at a Cancer Hospital

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Authors

NBN. Esther BabadyMemorial Sloan Kettering Cancer Center PMPeter A. MeadMemorial Sloan Kettering Cancer Center JSJeffrey StilesMemorial Sloan Kettering Cancer Center

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Implication

Comparative study demonstrates higher respiratory virus detection with FilmArray RP than xTAG RVP Fast in pediatric oncology patients, suggesting improved rapid diagnostic utility.

Key Points

To evaluate and compare the diagnostic performance and turnaround times of the Luminex xTAG RVP Fast assay and the Idaho Technology FilmArray RP assay in immunocompromised pediatric cancer patients.
Tested 358 respiratory specimens collected from 173 pediatric oncology patients.
Compared both multiplex PCR platforms against each other and against baseline results from direct fluorescence assay (DFA) and viral culture.
The overall virus detection rate across all tested methods was 24% for DFA/culture, 45% for xTAG RVP Fast, and 51% for FilmArray RP (P < 0.0001).
Concordance between the xTAG RVP Fast and FilmArray RP assays reached 84.5%.
FilmArray RP provided greater diagnostic sensitivity alongside a rapid turnaround time of approximately 1 hour.

Cite This Study

Babady et al. (2012) studied this question.

synapsesocial.com/papers/6a8be70e77493d51bfdef0f8 https://doi.org/10.1128/jcm.06186-11

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Implication

Comparative study demonstrates higher respiratory virus detection with FilmArray RP than xTAG RVP Fast in pediatric oncology patients, suggesting improved rapid diagnostic utility.

Comparison of the Luminex xTAG RVP Fast Assay and the Idaho Technology FilmArray RP Assay for Detection of Respiratory Viruses in Pediatric Patients at a Cancer Hospital

Discussion

Member takes

Implication

Key Points

Cite This Study

Comparison of the Luminex xTAG RVP Fast Assay and the Idaho Technology FilmArray RP Assay for Detection of Respiratory Viruses in Pediatric Patients at a Cancer Hospital

Discussion

Member takes

Implication

Key Points

Cite This Study

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