Key result
The FilmArray RP demonstrated 91.5% complete agreement with the xTAG RVP but detected more total viruses, including 21.6% more respiratory syncytial viruses.
Why the study?
Does the FilmArray RP method improve the detection of respiratory viruses compared to the xTAG RVP method in patient specimens?
Observational (n=200)
No
Does the FilmArray RP method improve the detection of respiratory viruses compared to the xTAG RVP method in patient specimens?
The FilmArray RP multiplex PCR method provides faster and more sensitive detection of respiratory viruses compared to the xTAG RVP method.
Answers are grounded in this paper and cite their sources.
May support FilmArray RP for higher viral yield in specimens; extends diagnostic comparisons but leaves open clinical impact.
We compared the FilmArray RP (Idaho Technology, Inc., Salt Lake City, UT) and the xTAG RVP (Luminex Corporation, Toronto, Canada) multiplex respiratory virus PCR methods for the detection of respiratory viruses in a set of 200 patient specimens frozen at -70 °C after standard viral culture and antigen detection methods were done. Both systems detected between 40 to 50% more viruses than traditional methods, primarily rhinoviruses and human metapneumovirus. The FilmArray RP detected significantly more total viruses either alone or as part of mixed infections than the xTAG RVP, as well as an additional 21.6% more respiratory syncytial viruses. The xTAG RVP requires 5 to 6 h with 2.5 to 3 h of hands-on time, while the FilmArray RP takes about an hour with 3 to 5 min of hands-on time, making it much easier to perform.
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Rand et al. (2011) conducted an observational in Respiratory viral infections (n=200). FilmArray RP vs. xTAG RVP was evaluated on Complete agreement between FilmArray RP and xTAG RVP (kappa 0.81, 95% CI 0.73-0.90). The FilmArray RP demonstrated 91.5% complete agreement with the xTAG RVP but detected more total viruses, including 21.6% more respiratory syncytial viruses.
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