Improved growth of enteric adenovirus type 40 in a modified cell line that can no longer respond to interferon stimulation

View Full Paper

Ask AI

Bookmark

Population

Human enteric adenovirus type 40 (HAdV-40) infected cells

Comparison

293-SV5/V cell line vs Parental 293 cells

Design

Preclinical

Authors

Discussion

May enhance lab-scale HAdV-40 yields; leaves open translation to clinical or vaccine manufacturing.

Population

Human enteric adenovirus type 40 (HAdV-40) infected cells

Intervention

293-SV5/V cell line (constitutively expresses V-protein of paramyxovirus Simian virus 5, degrading STAT1 to prevent IFN response)

Comparator

Parental 293 cells

Outcome

Virus production rate and viral titressurrogate

A modified 293 cell line defective in interferon response improves the propagation and yield of human enteric adenovirus type 40.

Sherwood et al. (2006) studied this question.

View Full Paper

Ask AI

Bookmark