Why the study?
Heart rate variability abnormalities reported in major depressive disorder and adverse childhood experiences are often confounded, and the influence of noradrenergic stimulation on heart rate variability reactivity remained unclear.
Does a single dose of yohimbine alter heart rate variability reactivity in unmedicated patients with major depressive disorder and/or adverse childhood experiences?
Population
Men and women with MDD and ACE (n = 25), MDD without ACE (n = 24), healthy with ACE (n = 27), and healthy without ACE (n = 48)
Comparison
Single dose of yohimbine 10 mg vs placebo on 2 separate days
Design
Randomized, double-blind, repeated measures study
Authors
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Yohimbine does not alter HRV reactivity in unmedicated MDD or ACE; challenges assumptions linking sympathetic activation to their autonomic differences.
Does a single dose of yohimbine alter heart rate variability reactivity in unmedicated patients with major depressive disorder and/or adverse childhood experiences?
Yohimbine-induced sympathetic activation does not significantly drive heart rate variability changes in patients with major depressive disorder or adverse childhood experiences.
Deuter et al. (2021) studied this question.
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