Key result
Depression plus reduced HRV in ACHD linked to ~7-fold higher risk of HF or death.
Why the study?
In adult congenital heart disease, major depressive disorder is a frequent comorbidity, but the prognostic relevance of major depressive disorder and heart rate variability was unknown.
Does major depressive disorder combined with reduced heart rate variability predict adverse clinical outcomes in adults with congenital heart disease?
Population
171 adult congenital heart disease patients
Comparison
Lower quartile of Symindex comorbid with MDD vs other patients
Design
Prospective cohort study
Follow-up
Mean 54.7 ± 14.9 months
Authors
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May warrant closer monitoring in ACHD; extends non-congenital MDD-HRV links but leaves practice change open.
Cohort (n=171)
No
Does major depressive disorder combined with reduced heart rate variability predict adverse clinical outcomes in adults with congenital heart disease?
Hazard Ratio: 7.04 (95% CI 1.87–26.5)
In adults with congenital heart disease, the combination of major depressive disorder and reduced heart rate variability strongly predicts heart failure, mortality, arrhythmias, and hospitalization.
Westhoff‐Bleck et al. (2021) conducted a cohort in Adult congenital heart disease (n=171). Major depressive disorder with reduced heart rate variability vs. Patients without major depressive disorder or with normal heart rate variability was evaluated on Decompensated heart failure and all-cause mortality (HF/death) (HR 7.04, 95% CI 1.87-26.5). In adults with congenital heart disease, major depressive disorder combined with reduced heart rate variability was associated with a significantly increased risk of heart failure or death (HR 7.04).
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