Key result
Low heart rate variability may account for a substantial part of the increased mortality risk associated with depression in patients with coronary heart disease.
Why the study?
Is depression associated with lower heart rate variability in patients with coronary heart disease?
Is depression associated with lower heart rate variability in patients with coronary heart disease?
Depression in patients with coronary heart disease is associated with lower heart rate variability, which may partially explain their increased risk of cardiac morbidity and mortality.
May refine risk stratification in depressed CHD patients; leaves open prospective validation of HRV-targeted interventions.
Depression is common in patients with coronary heart disease (CHD) and is a risk factor for cardiac morbidity and mortality in these patients. Depression is associated with autonomic nervous system dysfunction, which may at least partially explain this increased risk. Low heart rate variability (HRV), which reflects excessive sympathetic and/or inadequate parasympathetic modulation of heart rate, is a strong predictor of mortality in patients with CHD. Most studies-both in patients with stable CHD and in patients with a recent acute coronary event-have found HRV to be lower in depressed patients than in their nondepressed counterparts. This manuscript provides an overview of this literature and concludes that HRV may account for a substantial part of the risk associated with depression in CHD.
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Carney et al. (2009) conducted a review in Coronary heart disease and depression. Low heart rate variability may account for a substantial part of the increased mortality risk associated with depression in patients with coronary heart disease.
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