Why the study?
Does doxazosin compared to atenolol improve circulating levels of ET-1 and vWF in middle-aged men with essential hypertension?
Population
45 middle-aged men with essential hypertension
Comparison
Doxazosin (alpha-blocker) for 22 weeks vs Atenolol (beta-blocker) for 22 weeks
Design
RCT, randomized, open
Follow-up
22 weeks
Authors
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Supports considering endothelial profiles in antihypertensive selection; extends evidence for mechanism-specific effects beyond BP reduction.
Does doxazosin compared to atenolol improve circulating levels of ET-1 and vWF in middle-aged men with essential hypertension?
Alpha-blockers and beta-blockers exert different favorable effects on endothelial function markers in hypertensive men, suggesting drug-specific mechanisms beyond blood pressure lowering.
Seljeflot et al. (1999) studied this question.
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