Why the study?
Does an NAD-containing drug (NADCIN) improve hemodynamic reactions and baroreflex sensitivity in a rat model of nitroglycerin tolerance?
Does an NAD-containing drug (NADCIN) improve hemodynamic reactions and baroreflex sensitivity in a rat model of nitroglycerin tolerance?
In a rat model of nitrate tolerance, an NAD-containing drug restored hemodynamic responses and baroreflex sensitivity, suggesting a potential pharmacological approach to prevent nitroglycerin tolerance.
May attenuate nitroglycerin tolerance in rats; leaves open clinical translation and human trials.
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Gongadze et al. (2016) studied this question.
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