Population
Porcine coronary artery smooth muscle strips
Comparison
Endothelin-1 with pertussis toxin pretreatment… vs Untreated strips or KCl response
Design
Preclinical
Authors
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Hypothesis-generating for PT-sensitive G-protein pathways in coronary ET-1 signaling; clinical translation to humans remains untested.
Endothelin-1 induces contraction in porcine coronary arteries via two distinct signal transduction pathways, one of which involves a pertussis toxin-sensitive G-protein coupled to voltage-dependent calcium channels.
Kasuya et al. (1992) studied this question.
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