In DOCA-salt hypertensive rats, the exaggerated alpha 1b-adrenergic receptor-mediated inositol phosphate response is associated with blunted protein kinase C-mediated desensitization.
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Blunted PKC desensitization may underlie exaggerated adrenergic responses in hypertension; leaves open relevance to human disease.
Calderone et al. (1994) studied this question.
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