Why the study?
Are antibodies to myelin basic protein and oligodendrocytes present in the CSF of patients with multiple sclerosis and other neurological diseases?
Are antibodies to myelin basic protein and oligodendrocytes present in the CSF of patients with multiple sclerosis and other neurological diseases?
Antibodies against myelin basic protein and oligodendrocytes in the CSF appear to be a common feature of diseases involving demyelination.
May reflect shared anti-myelin reactivity across demyelinating diseases; hypothesis-generating and should not yet alter MS diagnostics or practice.
Cerebrospinal fluid (CSF) from 18 multiple sclerosis (MS) patients, 13 subacute sclerosing panencephalitis (SSPE) patients, 22 other neurological disease (OND) patients, and 7 neurotic patients as controls were tested in an 125I-labeled anti-human F(ab')2 binding assay for the presence of antibodies to normal human brain cells from tissue culture, human fibroblasts, plasma membranes of MS and normal human brain, myelin basic protein (MBP) and bovine oligodendrocytes. Antibodies to MBP and to oligodendrocytes were found in the CSF of MS, SSPE and OND patients. Absorption of CSF with bovine CNS myelin significantly diminished binding activity to oligodendrocytes. Antibodies in the CSF against MBP and oligodendrocytes, on which some myelin determinants are expressed, seem to be a common feature of diseases in which demyelination is a component.
No takes yet. Share an insight, caveat, or question.
Górny et al. (2009) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: