Why the study?
Are antibodies to myelin basic protein (MBP) elevated in the CSF of patients with multiple sclerosis and subacute sclerosing panencephalitis compared to controls?
Population
48 patients with multiple sclerosis and 30 patients with subacute sclerosing panencephalitis, plus controls
Comparison
Solid phase radioimmunoassay to detect… vs Controls
Design
Case-control
Authors
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Anti-MBP antibodies associate with MS and SSPE; supports autoimmunity hypothesis but leaves open causality and therapeutic relevance.
Are antibodies to myelin basic protein (MBP) elevated in the CSF of patients with multiple sclerosis and subacute sclerosing panencephalitis compared to controls?
Antibodies to myelin basic protein are elevated in the CSF of patients with MS and SSPE, supporting the hypothesis that autoimmunity to myelin antigens plays a role in pathogenesis.
Hillel Panitch (1980) studied this question.
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