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August 14, 2012Colorectal Disease

Early and late symptomatic anastomotic leakage following low anterior resection of the rectum for cancer: are they different entities?

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Why the study?

Are early and late symptomatic anastomotic leakages following low anterior resection of the rectum for cancer different entities?

Population

45 patients who developed symptomatic anastomotic leakage following low anterior resection of the rectum for…

Comparison

Early leakage vs Late leakage

Design

Cohort

Authors

HFHannah FloodeenOHOlof HallböökLinköping UniversityMRMartin RutegårdUppsala University

Discussion

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Member takes

Overview

Early leaks after low anterior resection link to more blood loss and poorer recovery; leaves open whether early and late leaks are distinct entities.

Structured PICO

Are early and late symptomatic anastomotic leakages following low anterior resection of the rectum for cancer different entities?

P
Population
45 patients who developed symptomatic anastomotic leakage following low anterior resection of the rectum (LAR) for cancer, identified from 234 patients entered into a randomized multicentre trial
I
Intervention
Early leakage (diagnosed during initial hospital stay on median postoperative day 8, n=27)
C
Comparator
Late leakage (diagnosed after hospital discharge at median postoperative day 22, n=18)
O
Outcome
Differences in patient characteristics, operative details, postoperative course and anatomical localization of the leakage

Early and late symptomatic anastomotic leakages after low anterior resection present with different clinical courses and operative characteristics, suggesting they may be distinct entities.

Cite This Study

Floodeen et al. (2012) studied this question.

synapsesocial.com/papers/6a8bede8039371f2a38973e2https://doi.org/10.1111/j.1463-1318.2012.03195.x
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Resection of the rectum with construction of a colonic reservoir and colo-anal anastomosis for carcinoma of the rectum1986 · 454 citations
  2. 2The Swedish rectal cancer registry2007 · 386 citations
  3. 3Systematic review of the definition and measurement of anastomotic leak after gastrointestinal surgery2001 · 730 citations
  4. 4Anastomotic leakage after anterior resection for rectal cancer: risk factors2009 · 282 citations