Why the study?
How do acetylsalicylic acid, flurbiprofen, and indomethacin compare in their ability to inhibit the ADP-induced platelet release reaction and prostaglandin synthesis in human platelets?
Population
Human blood platelets (in vitro) and platelets obtained from volunteers
Design
Preclinical
Authors
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Indicates prostaglandin-independent platelet effects for flurbiprofen/indomethacin; leaves open clinical antithrombotic relevance.
How do acetylsalicylic acid, flurbiprofen, and indomethacin compare in their ability to inhibit the ADP-induced platelet release reaction and prostaglandin synthesis in human platelets?
Flurbiprofen and indomethacin may inhibit the platelet release reaction via mechanisms independent of prostaglandin synthesis, unlike acetylsalicylic acid.
Cockbill et al. (1979) studied this question.
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