What question did this study set out to answer?

Determine whether high-content aminoglycoside disk diffusion tests can identify enterococcal strains showing high-level drug resistance and loss of penicillin synergy.

January 1, 1982Journal of Antimicrobial Chemotherapy

An aminoglycoside disk sensitivity test for use with enterococci

View Full Paper

Ask AI

Bookmark

Authors

SRSamuel L. RosenthalMarquette University LFLawrence F. FreundlichAlbert Einstein College of Medicine

Discussion

Member takes

Implication

Laboratory evaluation shows high-content aminoglycoside disk diffusion identifies resistant enterococci, suggesting loss of synergistic inhibition with penicillin combinations.

Key Points

Determine whether high-content aminoglycoside disk diffusion tests can identify enterococcal strains showing high-level drug resistance and loss of penicillin synergy.
Conducted antibiotic susceptibility testing using the standard Kirby-Bauer disk diffusion method.
Assayed enterococcal isolates against disks loaded with streptomycin (300 μg), gentamicin (120 μg), and tobramycin (120 μg).
High-content disks accurately identified enterococcal strains exhibiting high-level resistance to one or more aminoglycosides.
Identified resistant strains fail to demonstrate synergistic bactericidal inhibition when treated with penicillin combined with the respective aminoglycoside.

Cite This Study

Rosenthal et al. (1982) studied this question.

synapsesocial.com/papers/6a8bf3022372d24d7cfb3869 https://doi.org/10.1093/jac/10.5.459

View Full Paper

Ask AI

Bookmark

Implication

Laboratory evaluation shows high-content aminoglycoside disk diffusion identifies resistant enterococci, suggesting loss of synergistic inhibition with penicillin combinations.

An aminoglycoside disk sensitivity test for use with enterococci

Discussion

Member takes

Implication

Key Points

Cite This Study

An aminoglycoside disk sensitivity test for use with enterococci

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider