Population
Passive Heymann nephritis (PHN) rats and HK-2 cells
Comparison
Pioglitazone vs Vehicle and candesartan
Design
Preclinical
Follow-up
6 months (from months 2 to 8)
Authors
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Should not change clinical practice in glomerulonephritis; leaves open translation of nephrin restoration by pioglitazone to human studies.
Pioglitazone exerts an antiproteinuric effect in immune-mediated glomerulonephritis comparable to an angiotensin II receptor antagonist, mediated by enhancement of nephrin gene transcription.
Benigni et al. (2006) studied this question.
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