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Aryl iodides tethered to dehydroalanine units by two to four methylene groups undergo intramolecular Heck reactions under anhydrous Jeffery conditions to give 7-, 8- and 9-membered rings by the endo-mode of cyclisation; under harsher conditions, a palladium intermediate formed by the exo-mode of cyclisation is expressed as reduced products.
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Gibson et al. (1995) studied this question.
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