Population
Brain membrane
Design
Preclinical
Authors
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Hypothesis-generating for a Ca2+-calmodulin kinase mechanism in benzodiazepine anticonvulsant action; does not inform clinical practice.
Benzodiazepines may exert anticonvulsant and neuronal stabilizing effects via modulation of the Ca2+-calmodulin protein kinase system, representing a distinct receptor mechanism in the brain.
DeLorenzo et al. (1981) studied this question.
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