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December 4, 2010European Journal of Cardio-Thoracic SurgeryOpen Access

Clinical outcome and health-related quality of life after right-ventricular-outflow-tract reconstruction with an allograft conduit☆☆☆

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Why the study?

What are the long-term clinical outcomes and health-related quality of life after right-ventricular-outflow-tract reconstruction with an allograft conduit in pediatric and adult patients?

Population

463 pediatric and adult patients undergoing right-ventricular-outflow-tract reconstruction for right-sided…

Comparison

Right-ventricular-outflow-tract reconstruction… vs Age-adjusted Dutch population norms; no…

Design

Cohort

Follow-up

Mean 9 years (2 days-22 years)

Authors

MMMostafa M. MokhlesAl-Azhar UniversityPWPieter C. van de WoestijneErasmus MCPJPeter L. de JongErasmus MC

Discussion

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Overview

Supports allograft conduits for RVOT reconstruction; extends single-center data but leaves open randomized comparisons to alternatives.

Structured PICO

What are the long-term clinical outcomes and health-related quality of life after right-ventricular-outflow-tract reconstruction with an allograft conduit in pediatric and adult patients?

P
Population
463 pediatric and adult patients (mean age 19 years, range 1 week-66 years) undergoing right-ventricular-outflow-tract reconstruction for right-sided congenital heart malformations (n=308) or autograft procedures (n=155).
I
Intervention
Right-ventricular-outflow-tract reconstruction with an allograft conduit (435 pulmonary and 74 aortic allografts).
C
Comparator
Age-adjusted Dutch population norms (for quality of life assessment); no comparator for clinical outcomes.
O
Outcome
Patient survival, valve-related re-operation, valve-related events, and perceived quality of life assessed by Short Form-36.hard clinical

Right-ventricular-outflow-tract reconstruction with an allograft conduit provides excellent long-term survival and acceptable durability, with quality of life generally comparable to the normal population.

Cite This Study

Mokhles et al. (2010) studied this question.

synapsesocial.com/papers/6a8bf710167785443dca9555https://doi.org/10.1016/j.ejcts.2010.10.023

Topics

Congenital heart disease adults
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