November 1, 1994American Journal of Respiratory Cell and Molecular Biology

Hydrogen Peroxide Stimulates Mitogen-Activated Protein Kinase in Bovine Tracheal Myocytes: Implications for Human Airway Disease

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Population

Cultured bovine tracheal myocytes (quiescent cells)

Design

Preclinical

Follow-up

2 to 60 min

Authors

MAMark K. AbeUniversity of Illinois Chicago TCTsung-Shu Oliver ChaoMay Institute JSJulian SolwayUniversity of Chicago

Discussion

Member takes

Implication

Does not inform clinical practice; leaves open PKC as a target in ROS-driven airway remodeling.

Structured PICO

Population

Cultured bovine tracheal myocytes (quiescent cells)

Intervention

Hydrogen peroxide (H2O2) exposure (25 to 200 microns; 2 to 60 min)

Outcome

Mitogen-activated protein (MAP) kinase activation (phosphorylation at threonine and tyrosine residues and enzymatic activity)surrogate

Hydrogen peroxide stimulates MAP kinase activation in bovine tracheal myocytes via both PKC-dependent and independent pathways, suggesting a mechanism for reactive oxygen species in airway remodeling.

Cite This Study

Abe et al. (1994) studied this question.

synapsesocial.com/papers/6a8bf73bdd62e0468bc5d825 https://doi.org/10.1165/ajrcmb.11.5.7946386

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Bookmark

Hydrogen Peroxide Stimulates Mitogen-Activated Protein Kinase in Bovine Tracheal Myocytes: Implications for Human Airway Disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Hydrogen Peroxide Stimulates Mitogen-Activated Protein Kinase in Bovine Tracheal Myocytes: Implications for Human Airway Disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider