Hemolysis in Valvular Heart Disease

Editorials1 August 1966Hemolysis in Valvular Heart DiseaseBERNARD PIROFSKY, M.D., F.A.C.P.BERNARD PIROFSKY, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-2-373 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn recent years, surgical procedures have been developed to correct various forms of heart disease by the insertion of prosthetic devices. A hemolytic anemia that unexpectedly resulted from these procedures has presented the physician with a new syndrome having profound clinical and theoretical significance. This hemolytic anemia was first noted in the human and in experimental animals after insertion of a Hufnagel ball-valve prosthesis (1, 2). It was assumed that direct action of the ball-valve on erythrocytes was responsible for erythrocyte damage and destruction. Hemodynamic disturbance with turbulence of blood flow was subsequently implicated by several investigators as being the...References1. ROSEHUFNAGELFREISHARVEYPARTENOPE JCCAEDWPEA: The hemodynamic alterations produced by a plastic valvular prosthesis for severe aortic insufficiency in man. J. Clin. Invest. 33: 891, 1954. CrossrefMedlineGoogle Scholar2. STOHLMANSARNOFFCASE FSJRB: Hemolytic syndrome following insertion of a lucite ball valve prosthesis in the vascular system. Circulation 13: 586, 1956. CrossrefMedlineGoogle Scholar3. PO-TUM-FOKSCHUBOTHE FH: Studies on various factors influencing mechanical hemolysis of human erythrocytes. Brit. J. Haemat. 6: 355, 1960. CrossrefMedlineGoogle Scholar4. VERDONFORRESTERCROSBY TARHWH: Hemolytic anemia after open heart repair of ostium primum defects. New Eng. J. Med. 269: 444, 1963. CrossrefMedlineGoogle Scholar5. SAYEDDACIEHANDLEYLEWISCLELAND HMJVDASMWP: Hemolytic anaemia of mechanical origin after open heart surgery. Thorax 16: 356, 1961. CrossrefMedlineGoogle Scholar6. BRODEURSUTHERLANDKOLERSTARRKIMSEYGRISWOLD MTDWRDAJAHE: Red cell survival in patients with aortic valvular disease and ball-valve prosthesis. Circulation 32: 570, 1965. CrossrefMedlineGoogle Scholar7. DAMESHEK W Discussion by : Case records of the Massachusetts General Hospital. New Eng. J. Med. 271: 898, 1964. CrossrefMedlineGoogle Scholar8. DECESARERATHHUFNAGEL WCC: Hemolytic anemia of mechanical origin with aorticvalve prosthesis. New Eng. J. Med. 272: 1045, 1965. CrossrefMedlineGoogle Scholar9. WALSHBRODEURRITZMANNSUTHERLANDSTARR JRMTLWDWA: Urinary iron excretion in patients with prosthetic heart valves. JAMA, in press. Google Scholar10. PIROFSKYSUTHERLANDSTARRGRISWOLD BDWAHE: Hemolytic anemia complicating aortic-valve surgery. New Eng. J. Med. 272: 235, 1965. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Oregon Medical School Portland, Ore. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHemolytic anemia due to native valve subacute endocarditis with Actinomyces israelii infectionHemolytic anemia in a patient with hypertrophic obstructive cardiomyopathyMechanisms of hemolysis with mitral prosthetic regurgitation study using transesophageal echocardiography and fluid dynamic simulationMechanical Hemolytic Anemia After Repair of Ruptured Chordae Tendineae of Mitral Valve ApparatusHypothesis. Auto-antibodies and immunological theories: An analytical reviewMASSIVE HEMOLYSIS AFTER DOUBLE VALVE REPLACEMENTHemolytic Anemia in Series 2300 and 2310 Starr-Edwards Prosthetic ValvesHematologic Effects of Cardiac DiseaseIntravascular Hemolysis and Consumption Coagulop- Athy in Defective Aortic Valve Prosthesis. Transient, Beneficial Effect of Heparin and Recovery Following Successful Replacement of ValveChronic Intravascular Hemolysis after Aortic Valve ReplacementMECHANICAL HEMOLYSIS IN AORTIC VALVULAR DISEASE AND AORTIC BALL-VALVE PROSTHESISParavalvular leaks and hemolytic anemia following insertion of Starr-Edwards aortic and mitral valvesLangzeitbeobachtungen nach künstlichem Ersatz der Aorten- bzw. Mitralklappe unter besonderer Berücksichtigung von Klappeninsuffizienzen, Thrombembolien, Endokarditiden und BallveränderungenSerum Lactate Dehydrogenase Elevation in Ambulatory Cardiac Patients 1 August 1966Volume 65, Issue 2Page: 373-376KeywordsBlood flowCardiovascular therapyHemodynamicsHemolytic anemia Issue Published: 1 August 1966 PDF downloadLoading ...