What is the clinical evidence from this study?

Study design: Review. Population: Aortic Valve Disease and Hemolytic Anemia. Intervention: Endocardial prostheses and aortic valve replacement. Primary outcome: Hemolytic anemia.

What question did this study set out to answer?

To review the clinical characteristics and mechanical origins of intravascular hemolytic anemia occurring in patients with aortic valve disease and prosthetic cardiac valve replacements.

August 1, 1966Annals of Internal Medicine

Aortic Valve Disease and Hemolytic Anemia

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Key result

Endocardial prostheses and aortic valve replacements are associated with a postoperative syndrome of hemolytic anemia, hemoglobinemia, hemosiderinuria, and schistocytes.

Population

Patients with aortic valve disease or ostium primum defects undergoing valve replacement or repair with…

Design

Other

Authors

DWDavid W. WestringMarquette University

Discussion

Member takes

Implication

Recognizing this syndrome warrants hemolysis monitoring after valve replacement; leaves open relevance to contemporary prostheses.

Key Points

To review the clinical characteristics and mechanical origins of intravascular hemolytic anemia occurring in patients with aortic valve disease and prosthetic cardiac valve replacements.
Evaluated clinical literature and hematologic reports of postoperative anemia occurring after placement of early endocardial prostheses and intracardiac Teflon repairs.
Assessed laboratory signs of mechanical intravascular hemolysis, including hematocrit declines, hemoglobinemia, hemosiderinuria, and peripheral blood poikilocytosis.
Endocardial ball-valve prostheses and corrective Teflon patches consistently caused intravascular erythrocyte destruction and marked hematocrit reductions.
Complications including prosthetic cusp tears and detachment of valves from muscular anchor sites dramatically accelerated mechanical red cell fragmentation, producing circulating schistocytes.

Structured PICO

Population

Patients with aortic valve disease or ostium primum defects undergoing valve replacement or repair with endocardial prostheses.

Exposure

Endocardial prostheses (e.g., Hufnagel ball valve, Starr-Edwards valve) or Teflon repairs

Outcome

Postoperative syndrome of anemia, hemoglobinemia, hemosiderinuria, and schistocytes (hemolytic anemia)safety

Mechanical hemolysis is a recognized complication following the implantation of early endocardial prostheses for aortic valve disease.

Cite This Study

David W. Westring (1966) conducted a review in Aortic Valve Disease and Hemolytic Anemia. Endocardial prostheses and aortic valve replacement was evaluated on Hemolytic anemia. Endocardial prostheses and aortic valve replacements are associated with a postoperative syndrome of hemolytic anemia, hemoglobinemia, hemosiderinuria, and schistocytes.

synapsesocial.com/papers/6a93aaee314706f3c6462c04 https://doi.org/10.7326/0003-4819-65-2-203

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Aortic Valve Disease and Hemolytic Anemia

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Aortic Valve Disease and Hemolytic Anemia

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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