Population
Isolated perfused rat atria
Comparison
Exposure to anoxic conditions, with or without… vs Baseline and untreated anoxic conditions
Design
Preclinical
Authors
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Should not alter clinical anoxia management; extends mechanistic evidence for endothelin-prostaglandin mediation of ANP in rat atria.
Anoxia-induced ANP release in isolated rat atria is mediated by locally produced endothelin, which in turn stimulates the production of prostaglandins responsible for the increased secretion.
Skvorak et al. (1996) studied this question.
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