Why the study?
Does inactivated poliovirus vaccine protect transgenic mice expressing the human poliovirus receptor against type 3 poliovirus challenge?
Population
Transgenic (Tg) mice expressing the human poliovirus receptor (PVR)
Comparison
Inactivated poliovirus vaccine or polio-immune… vs Unimmunized mice or different formulations of IPV
Design
Preclinical
Authors
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Single monovalent IPV injection protects in PVR mice; leaves open human schedule optimization pending clinical trials.
Does inactivated poliovirus vaccine protect transgenic mice expressing the human poliovirus receptor against type 3 poliovirus challenge?
The transgenic PVR mouse model can effectively evaluate IPV potency and formulations, demonstrating that neutralizing antibodies are sufficient for immunity.
Taffs et al. (1997) studied this question.
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