What question did this study set out to answer?

Determine whether poliomyelitis virus circulates in the bloodstream during mild, abortive, or asymptomatic stages of infection.

Poliomyelitis Virus in Human Blood During the "Minor Illness" and the Asymptomatic Infection.

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Population

4 children in one family during a poliomyelitis epidemic in Ohio in 1952

Design

Case_series

Authors

Poliovirus viremia without paralysis warrants no intervention; case reports leave open determinants of progression to major disease.

Determine whether poliomyelitis virus circulates in the bloodstream during mild, abortive, or asymptomatic stages of infection.
Assessed four children from a single family during a 1952 poliomyelitis outbreak in Ohio.
Collected and analyzed blood samples, throat swabs, and rectal swabs to isolate the poliomyelitis virus.
Isolated poliomyelitis virus from the blood, throat swabs, and rectal swabs of all four children, including three with minor illness and one who was asymptomatic.
Observed no clinical progression to major paralytic or nonparalytic poliomyelitis in any of the four children despite confirmed viremia.

Population

4 children in one family during a poliomyelitis epidemic in Ohio in 1952 (3 with minor illness or abortive poliomyelitis, 1 asymptomatic)

Outcome

Isolation of poliomyelitis virus from blood, throat, and rectal swabssurrogate

Poliomyelitis virus can be present in the blood during minor illness or asymptomatic infection without progressing to major paralytic disease.

Horstmann et al. (1953) studied this question.

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