A look at the diastolic function in severe sepsis and septic shock

A look at the diastolic function in severe sepsis and septic shock EDITORIAL Myocardial dysfunction in sepsis is a complex entity due to the dynamic adaptation of the cardiovascular system to the disease process, the host response, and the effects of resuscitation.The pathophysiology of this entity is multifactorial; systemic, cellular, and extracellular mechanisms have been described, including maldistribution of coronary blood flow, myocardial injury, complement-triggered (C5a) myocyte contractile failure, cytokine-induced neutrophil activation (tumor necrosis factor, interleukin-1β, interleukin-6), dysregulation of calcium handling, and cytopathic hypoxia due to mitochondrial dysfunction. (1,2)ardiovascular compromise is a central component of multiple organ dysfunction syndrome, an often fatal consequence of severe sepsis and septic shock.There is a sizable body of work on left ventricular systolic dysfunction in sepsis, (3,4) whereas other forms of myocardial dysfunction have been often overlooked.These variants include left ventricular diastolic dysfunction (5)(6)(7)(8) and right ventricular dysfunction, (9,10) which have different treatment options and prognostic implications.Interestingly, all types of myocardial dysfunction can be present in isolation or in combination and can be fully reversible with resolution of critical illness. (5,11)ith the use of tissue Doppler imaging (TDI), a technique that has gained acceptance amongst cardiologists and intensivists for the evaluation of diastolic function, it has become evident that diastolic dysfunction is indeed common in critically ill patients. (12)TDI is an echocardiographic technique based on measurements of myocardial velocities, (13) which are low frequency, high-amplitude signals filtered from conventional Doppler imaging. (14)It is particularly useful as a measure of ventricular relaxation and ventricular filling pressures. (15)(18)(19)(20)(21)(22) In this issue of the Revista Brasileira de Terapia Intensiva, an interesting, single-center prospective cohort study confirmed the importance of diastolic dysfunction in patients with severe sepsis and septic shock.The authors studied 53 patients with the aim of assessing the prevalence of myocardial dysfunction both at ICU admission and one week later and also of evaluating the impact of left ventricular systolic and diastolic dysfunction on ICU mortality. (23) detailed echocardiographic examination was performed within 48 hours of ICU admission and 7-10 days later, which included M-mode, two-dimension, and Doppler echocardiography.Systolic and diastolic function, including TDI, as well as right ventricular assessment with tricuspid annular plane systolic excursion, were carefully evaluated by a single cardiologist specialized in echocardiography.