Why the study?
Does donepezil improve cardiac remodeling and autonomic balance in a rat model of heart failure?
Population
Rat model of heart failure following extensive healed myocardial infarction
Comparison
Donepezil administered in drinking water vs Nontreated counterparts
Design
Preclinical
Authors
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Attenuates ventricular remodeling in experimental HF; extends vagal stimulation data but leaves open clinical translation.
Does donepezil improve cardiac remodeling and autonomic balance in a rat model of heart failure?
In a rat model of heart failure, donepezil reproduced the anti-remodeling effects of electrical vagal stimulation by improving hemodynamics and suppressing neurohumoral factors.
Okazaki et al. (2009) studied this question.
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