January 1, 1968Archivum histologicum japonicumOpen Access

Functional Morphology of the Pars Intermedia of the Rat Hypophysis as Revealed with the Electron Microscope

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Population

Rats (intact, adrenalectomized, and laparotomized)

Design

Preclinical

Follow-up

Up to 4 weeks

Authors

YKYasuo KobayashiHokkaido University

Discussion

Member takes

Implication

Rat pars intermedia granule responses to stress and dexamethasone are hypothesis-generating; leaves open any relevance to human ACTH regulation.

Structured PICO

Population

Rats (intact, adrenalectomized, and laparotomized)

Intervention

Dexamethasone (single injection or prolonged daily injection), adrenalectomy, and laparotomy

Outcome

Morphological changes in the pars intermedia (specifically light cells of the first type) and electron density of secretory granules as revealed by electron microscopysurrogate

The rat pars intermedia responds to stressful stimuli and dexamethasone with morphological changes in secretory granules, suggesting a role in ACTH-like substance production.

Cite This Study

Yasuo Kobayashi (1968) studied this question.

synapsesocial.com/papers/6a8bfea2f71b672e3df4a9d6 https://doi.org/10.1679/aohc1950.29.105

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Implication

Rat pars intermedia granule responses to stress and dexamethasone are hypothesis-generating; leaves open any relevance to human ACTH regulation.

Functional Morphology of the Pars Intermedia of the Rat Hypophysis as Revealed with the Electron Microscope

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Functional Morphology of the Pars Intermedia of the Rat Hypophysis as Revealed with the Electron Microscope

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider