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August 24, 2026Drug Delivery and Translational ResearchOpen Access

Immunotherapeutic efficacy of transdermal delivery of anti-CD3 antibody-conjugated magnetic nanoparticles using a hyaluronic acid-based dissolving microneedle patch

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Authors

SCSang-Heon ChoiJCJong‐Gu ChoiMHMahbub Hasan

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Overview

Preclinical study demonstrates reduced inflammatory cytokines in mice using anti-CD3 nanoparticle microneedle patches, indicating potential for minimally invasive transdermal immunotherapy.

Key Points

  • To develop a biodegradable hyaluronic acid dissolving microneedle patch loaded with anti-CD3 antibody-conjugated magnetic nanoparticles and evaluate its feasibility for transdermal immunotherapy.
  • Covalently conjugated anti-CD3 monoclonal antibodies to amine-functionalized Fe3O4 nanoparticles and integrated them into hyaluronic acid microneedles using mold replication.
  • Treated a concanavalin A-induced inflammatory mouse model with one, two, or three microneedle patches prior to challenge and measured circulating serum IL-6 and IFN-gamma levels.
  • Fabricated microneedle arrays demonstrated uniform needle morphology and maintained the magnetic responsiveness of embedded nanoparticles.
  • Microneedle patch treatment reduced serum IL-6 and IFN-gamma concentrations relative to untreated controls, exhibiting a patch-number-associated trend toward greater cytokine suppression.

Cite This Study

Choi et al. (2026) studied this question.

synapsesocial.com/papers/6a8c005bbca056c88e6df0a5https://doi.org/10.1007/s13346-026-02205-7
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