Population
n=2 patients with cocaine abuse-associated malignant hypertension and acute renal failure
Design
Case_series
Authors
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Alerts clinicians to cocaine exposure in unexplained TMA with hypertension; leaves open causal mechanisms and need for larger studies.
Cocaine abuse can lead to malignant hypertension and acute renal failure characterized by thrombotic microangiopathy, likely mediated by endothelial injury and platelet activation.
Gu et al. (2007) studied this question.
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