Rhabdomyolysis Related to Cocaine Abuse

Brief Reports15 August 1988Rhabdomyolysis Related to Cocaine AbuseBarry C. Herzlich, MD, Edward L. Arsura, MD, Murali Pagala, PhD, David Grob, MDBarry C. Herzlich, MDSearch for more papers by this author, Edward L. Arsura, MDSearch for more papers by this author, Murali Pagala, PhDSearch for more papers by this author, David Grob, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-4-335 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe rapid escalation in cocaine consumption in recent years has led to the recognition of new toxicities (1). Muscle necrosis caused by cocaine alone or with other factors has rarely been appreciated. We describe the cases of three patients with rhabdomyolysis resulting in acute renal failure in which cocaine was felt to play a major role, and discuss the manifestations and possible pathogenesis of this disorder.Patient 1A 27-year-old man was hospitalized with bilateral flank pain. The patient had smoked cocaine alkaloid (crack) every 3 to 4 hours for 4 consecutive days. On day 5, he became delirious and...References1. CreglerMark LH. Medical complications of cocaine abuse. N Engl J Med. 1986;315:1495-500. CrossrefMedlineGoogle Scholar2. KofflerFriedlerMassry ARS. Acute renal failure due to nontraumatic rhabdomyolysis. Ann Intern Med. 1976;85:23-8. LinkGoogle Scholar3. RichterChallenorPearsonKagenHamiltonRamsey RRJLLW. Acute myoglobinuria associated with heroin addiction. JAMA. 1971;261:1172-6. CrossrefGoogle Scholar4. KendrickHullKnochel WAJ. Rhabdomyolysis and shock after intravenous amphetamine administration. Ann Intern Med. 1977;86:381-7. LinkGoogle Scholar5. FarberHuertan SV. Intravenously injected marijuana syndrome. Arch Intern Med. 1976;136:337-9. CrossrefMedlineGoogle Scholar6. SchwartzMcAfee JR. Cocaine and rhabdomyolysis [Letter]. J Fam Pract. 1987;24:209. MedlineGoogle Scholar7. MerigianRoberts KJ. Cocaine intoxication: hyperpyrexia, rhabdomyolysis and acute renal failure. Clin Toxicol. 1987;25:135-48. Google Scholar8. KrohnSlowman-KovacsLeapman KSS. Cocaine and rhabdomyolysis [Letter]. Ann Intern Med. 1988;108:639-40. LinkGoogle Scholar9. VenkatachariPagalaHerzlichNambaGrob SMBTD. Effect of cocaine on neuromuscular function in isolated phrenic nervediaphragm of mouse. FASEB J. 1988;2:A1138. Google Scholar10. KostenKleber TH. Sudden death in cocaine abusers: relation to neuroleptic malignant syndrome [Letter]. Lancet. 1987;1:1198. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From Maimonides Medical Center and SUNY Health Science Center, Brooklyn, New York. For current author addresses, see end of text. 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Kaehny, MD 15 August 1988Volume 109, Issue 4Page: 335-336KeywordsAcute renal failureAlkaloidsCocaineMusclesMuscular dystrophiesNecrosisPathogenesisRhabdomyolysisToxicity Issue Published: 15 August 1988 PDF DownloadLoading ...