Why the study?
The triglyceride-glucose index predicts heart failure risk in coronary artery disease, but its correlation with myocardial work measurements and role in detecting early subclinical cardiac dysfunction remained to be investigated.
Does an elevated TyG index correlate with early subclinical myocardial dysfunction (global waste work) in patients with CAD?
Does an elevated TyG index correlate with early subclinical myocardial dysfunction (global waste work) in patients with CAD?
An elevated TyG index is independently associated with increased global waste work, suggesting it may serve as a marker for early subclinical myocardial dysfunction in CAD patients.
TyG index may flag subclinical myocardial impairment in CAD; leaves open its incremental value for risk stratification.
Background: Triglyceride-glucose (TyG) index, as an effective surrogate marker of insulin resistance, has shown predictive value in the risk of heart failure in patients with coronary artery disease (CAD). This study aims to investigate the correlation between TyG index and myocardial work measurements in CAD, and to explore its role in detecting early subclinical cardiac dysfunction. Methods: This cross-sectional study included 267 patients diagnosed with CAD and excluding left ventricular myocardial dysfunction in Beijing Hospital. Participants were divided into two groups according to the TyG index level, and myocardial work measurements were compared between groups. The correlation was explored between gradually increased TyG index and subclinical myocardial function in CAD patients. Results: We observed that TyG index was significantly correlated with the global waste work (GWW), and the value of GWW increased progressively with the elevation of TyG index. After adjusting for the effects of confounding factors, TyG index was still independently associated with GWW. Conclusion: An elevated TyG index was independently correlated with early subclinical myocardial dysfunction in CAD patients. Our study demonstrated that the strict control of TyG index may be conducive to forestall the progression of clinical heart failure in CAD patients.
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Meng et al. (2024) studied this question.
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